A bridge has been closed and roads and farmland could be flooded while river levels remain high, the Environment Agency (EA) has warned.
The Radwell bridge over the River Great Ouse, near Bedford, is unpassable due to flooding and three other bridges in Bedfordshire are being monitored.
River levels are expected to remain high in Buckinghamshire, Essex, Cambridgeshire and Northamptonshire.
The alerts come a year on from flooding in much of the region last December.
In its latest alerts, the EA said low-lying paths and roads near affected rivers should be avoided, though no rainfall was predicted for Monday.
The advisory included the River Great Ouse between Newport Pagnell, Buckinghamshire, to Roxton, near Bedford, and bridges at Felmersham, Oakley and Harrold.
There is an alert in place for the River Tove in Northamptonshire, from Towcester to Cosgrove, near Milton Keynes, and also along the River Rhee in Cambridgeshire, from Guilden Morden, near the border with Hertfordshire and Bedfordshire, to Haslingfield, near Cambridge.
In Essex, heavy rainfall has affected Middle River Roding, particularly around Loughton and Abridge.
"We are closely monitoring the situation, checking rivers for blockages and clearing debris from structures," the Environment Agency said.
Find BBC News: East of England on Facebook, Instagram and Twitter. If you have a story suggestion email eastofenglandnews@bbc.co.uk
Check for flooding in England
Police release picture of 14-year-old missing from Cranfield since Christmas Day
PM urges people to get vaccinated ahead of New Year celebrations
UPDATE: Bedfordshire records over 6,600 new Covid cases during Christmas weekend
Leighton-Linslade Thanksgiving and Reflection event lined up to acknowledge Covi…
Aylesbury police officer Ashleigh Frith set for misconduct hearing
Man hospitalised after being hit by a Skoda while lying on Milton Keynes road
Information about BBC links to other news sites
US reports Covid record as Europe's cases soar
No plans to cut isolation period in England
Hong Kong news website to shut after police raid
How is it going with those grand COP26 commitments?
The photos that captured the world in 2021
Fighting to learn in Venezuela. Video
The mystery of the Queen's birthplace
Music preview 2022: The biggest releases, tours and films
Why Mauritius is losing its seashells
BBC Culture: Why being rich is no longer glamorous
Watch: Working for a piece of bread
‘I had to tell my deaf father that he was dying’
A beginner's guide to identifying birdsong
How many can you recognise by sound alone?
From classical masterpieces to contemporary jazz!
Laura Mvula plays some of her favourite music from 2021
© 2021 BBC. The BBC is not responsible for the content of external sites. Read about our approach to external linking.

source